Mac and Cheese Meatloaf Casserole is a comforting and hearty dish that combines two beloved meals into one. It is perfect for family dinners or gatherings, as it is filling and packed with flavor. The mix of ground beef, macaroni, and cheese creates a delicious taste that everyone will enjoy. Plus, it’s easy to prepare and can be ready in under an hour.
How to Make Mac and Cheese Meatloaf Casserole
Ingredients:
- 1 cup ketchup
- 1 cup Sweet Baby Ray’s Hickory & Brown Sugar barbecue sauce
- 1 pound ground beef
- 1 cup cooked macaroni
- 1 cup shredded cheddar cheese
- 1/2 cup breadcrumbs
- 1/2 cup chopped onion
- 2 eggs
- 1 teaspoon garlic powder
- 1 teaspoon salt
- 1 teaspoon pepper
Directions:
- Preheat the oven to 350°F (175°C).
- In a large bowl, combine ground beef, cooked macaroni, shredded cheddar cheese, breadcrumbs, chopped onion, eggs, garlic powder, salt, and pepper. Mix until well combined.
- In a separate bowl, combine ketchup and barbecue sauce.
- Spread half of the sauce mixture in the bottom of a casserole dish.
- Layer the meat mixture on top and pour the remaining sauce over it.
- Bake for 45 minutes or until cooked through. Let cool for a few minutes before serving.
How to Serve Mac and Cheese Meatloaf Casserole
This dish is best served warm. You can pair it with a simple green salad or steamed vegetables for a complete meal. Feel free to garnish with additional cheese or fresh herbs for extra flavor.
How to Store Mac and Cheese Meatloaf Casserole
Store any leftovers in an airtight container in the refrigerator. It will stay fresh for up to 3-4 days. You can reheat it in the microwave or oven until warmed through.
Tips to Make Mac and Cheese Meatloaf Casserole
- Make sure to cook the macaroni al dente, as it will cook more in the oven.
- For added flavor, you can mix in cooked bacon or sausage with the ground beef.
- Adjust the seasonings to suit your taste. You could add chili powder for some heat or Italian herbs for a different flavor profile.
Variation
You can make a chicken version of this casserole by using ground chicken instead of beef. Additionally, you can swap the cheddar cheese for mozzarella or pepper jack cheese for a unique flavor.
FAQs
Can I make this recipe ahead of time?
Yes, you can prepare the casserole and refrigerate it unbaked for up to a day. Just add a few extra minutes to the baking time.
Can I freeze Mac and Cheese Meatloaf Casserole?
Yes, you can freeze it before baking. Wrap it tightly in plastic wrap and then foil. It will last for up to 3 months in the freezer. Thaw in the fridge before baking.
What can I serve with Mac and Cheese Meatloaf Casserole?
This dish pairs well with a variety of sides, such as garlic bread, steamed broccoli, or fresh coleslaw.

Mac and Cheese Meatloaf Casserole
Ingredients
- 1 cup ketchup
- 1 cup Sweet Baby Ray’s Hickory & Brown Sugar barbecue sauce
- 1 pound ground beef
- 1 cup cooked macaroni
- 1 cup shredded cheddar cheese
- 1/2 cup breadcrumbs
- 1/2 cup chopped onion
- 2 eggs
- 1 teaspoon garlic powder
- 1 teaspoon salt
- 1 teaspoon pepper
Instructions
- Preheat the oven to 350°F (175°C).
- In a large bowl, combine ground beef, cooked macaroni, shredded cheddar cheese, breadcrumbs, chopped onion, eggs, garlic powder, salt, and pepper. Mix until well combined.
- In a separate bowl, combine ketchup and barbecue sauce.
- Spread half of the sauce mixture in the bottom of a casserole dish.
- Layer the meat mixture on top and pour the remaining sauce over it.
- Bake for 45 minutes or until cooked through. Let cool for a few minutes before serving.
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